DNA Implementation of a Royal Road Fitness Evaluation
نویسندگان
چکیده
A model for DNA implementation of Royal Road evolutionary computations is presented. An encoding for a Royal Road problem is presented. Experimental results utilizing 2-d denaturing gradient gel electrophoresis (2-d DGGE) and polyacrylamide gel electrophoresis (PAGE) for separation by tness in this sample Royal Road problem are shown. Suggestions for possible use of the MutS and MutY proteins as tools for separation by tness are given. Plans for future experiments and implementation are discussed.
منابع مشابه
Physical Separation of DNA According to Royal Road Fitness
We want to implement evolutionary computation using DNA, with trillions of candidate solutions being simultaneously evaluated for fitness. Unsurprisingly, the most difficult aspect is designing and implementing laboratory methods for physical separation of DNA strands according to “fitness.” We propose a DNA strand design suited to the classical Royal Road Problem. And we propose companion labo...
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